The Micromechanical Signature of Pituitary Adenomas: New Perspectives for the Diagnosis and Surgery
نویسندگان
چکیده
Pituitary adenomas are common tumors in the skull base that associated with significant morbidity due to local compressive effects, hormonal hypersecretion, or treatment-associated endocrine deficiency. often surgically resected improve clinical symptoms, help of magnetic resonance imaging (MRI) locate tumor tissues. But still a large proportion adenoma fail being located, either too small not dense enough. In addition, normal and tissues do always show optical contrast endoscopic endonasal trans-sphenoidal surgery. Finding new markers delineate tissue has become mandatory surgical procedure limit relapses. Herein, an indentation-type atomic force microscope is used two orders magnitude softer than tissues, independent type secretion. This softening correlates degradation reticulin, IV collagen, laminin scaffolds all tumors. difference suggests intraoperative lesion localization margin assessment could be evaluated by approach based on stiffness measurement.
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ژورنال
عنوان ژورنال: Advanced nanoBiomed research
سال: 2021
ISSN: ['2699-9307']
DOI: https://doi.org/10.1002/anbr.202000085